Elements of the living organism:
1. Elements in large scale: 11 elements
H, C, N, O, Na, Mg, P, S, Cl, K, Ca
2. Elements in small scale: 7 elements
Mn, Fe, Co, Cu, Zn, I, Mo
3. Elements of a few species: 7 elements
B, F, Si, V, Cr, Se, Sn
Metal site Function
1. Metal complexes of porphyrins and corrins
- Iron porphyrins
= Hemoglobin & Myoglobin O2 transport
= Cytochromes Redox catalysts
- Vitamin B12
=Cobalt corrinoid Radical catalyst Methyltransferase
2. Bridged bimetallic complexes
- Fe2 clusters
= Hemerythrin O2 transport
= Methane Monooxygenase Hydroxylase
= Ribonucleotide Reductase RR2 Radical generation
- Cu2 clusters
= Hemocyanin O2 transport
- Mn2 clusters
= O2 -evolving complex Photosystem II
= Mn-Catalase H2O2 disproportionation
- Zn2 clusters
= Zinc aminopeptidases Peptide cleavage
- Ni2 clusters
= Urease Hydrolysis of urea
3. Fe-S clusters Electron transfer
4. Mo-pterin Xanthine oxidase
5. Zinc fingers DNA binding
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